Professor Sheng-Tung Huang Ph.D. 

黃聲東 教授  

Institute of Biochemical and Biomedical Engineering

生化與生醫工程研究所

National Taipei University of Technology (TAIPEI TECH)

 

E-mail : ws75624@ntut.edu.tw

Phone: (02) 2771-2171 2525

 

Education (學歷):

1994-1998   PhD Bio-Organic Chemistry, Brandeis University, Waltham, USA

                    有機生化博士學位 

1993-1994   Master of Biochemistry, University of California Riverside, Riverside, USA

                    生化碩士學位 

1989-1993   Bachelor of Science in Biochemistry, University of California Riverside, Riverside, USA

                    生化學士學位

 

Experiences ():

2012-2015      Dean, Office of International Affairs,

      National Taipei University of Technology

                       (國立台北科技大學生國際事務處 兼任國際長)


2011-2012      Department Chair, Institute of Biotechnology,

      National Taipei University of Technology

                       (國立台北科技大學生物科技研究所 兼任所長)


2009-Present  Professor, Institute of Biochemical and Biomedical Engineering

     National Taipei University of Technology

                       (國立台北科技大學生化與生醫工程研究所 教授)


 2007-2009    Section Chief, Office of General Affairs

     National Taipei University of Technology

                      (國立台北科技大學總務處經營管理組 兼任組長)


 2005-2009    Associate Professor, Institute of Biotechnology,

     National Taipei Univeristy of Technology

                      (國立台北科技大學生物科技研究所 副教授)


2004-2005     Associate Professor, Department of Biochemistry

     Taipei Medical University   

                       (台北醫學大學醫學系 副教授)


2000-2004     Assistance Professor, Department of Biochemistry

     Taipei Medical University 

                      (台北醫學大學醫學系 助理教授)


 1998-2000    Chemist/ Scinopharm Taiwan LTD

                      (研究員/ 台灣神隆股份有限公司 )

 

 

Research

My research interests include developing innovated fluorogenic and electrochemical active molecules for biosensors, bioelectronics and bio-imaging, synthesizing novel anti-cancer agents, design and synthesizing DNA intercalators for electrochemical gene detection and preparing new efficient water vapor impermeable packaging materials for new generation of bendable solar cells and bio-electronic devices.

 


 

Published Papers

1. Kesavan Manibalan, Veerappan Mani, Chih-Hung Huang, Sheng-Tung Huang* and Pu-Chieh Chang (2015, Aug). A new electrochemical substrate for rapid and sensitive in vivo monitoring of β-galactosidase gene expressions. Analyst, 140, 6040-6046.

2. Rajkumar Devasenathipathy, Veerappan Mani, Shen-Ming Chen, Sheng-Tung Huang,∗∗ Tsung-Tao Huang, Chun-Mao Lin, Kuo-Yuan Hwa, Ting-Yo Chen, Bo-Jun Chen (2015, Jun). Glucose biosensor based on glucose oxidase immobilized at goldnanoparticles decorated graphene-carbon nanotubes. Enzyme and Microbial Technology, 78, 40-45.

3.    Veerappan Mani,Rajkumar Devasenathipathy, Shen-Ming Chen,* V. S. Vasantha,* M. Ajmal Ali,Sheng-Tung Huang, and Fahad M. A. Al-Hemaid (2015, Jun). A simple electrochemical platform based on pectin stabilized gold nanoparticles for picomolar detection of biologically toxic amitrole. Analyst, 140, 5764-5771.

4.  Shiuh-Bin Fang, Hsin-Yu Ko, Sheng-Tung Huang, Chih-Hung Huang, Li-Ting Li, Chia-Chun Chen, Ke-Chuan Wang, Cheng-Pin Pai, Hung-Chang Lee, and Hsu-Wei Fang (2015 April) Cinnamomum osmophloeum extracts inhibit growth of Helicobacter pylori and post infectious interleukin-8 expression in human gastric epithelial cells, RSC Advances, 5, 22097.

5. Veerappan Mani, Rajkumar Devasenathipathy, Shen-Ming Chen, Jiun-An Gu, Sheng-Tung Huang (2015 April) Synthesis and characterization of graphene-cobalt phthalocyanines and graphene-iron phthalocyanine composites and their enzymatic fuel cell application. Renewable Energy, 74, 867-874.

6. Rajkumar Devasenathipathy, Veerappan Mani, Shen-Ming Chen, Kesavan Manibalan, Sheng-Tung Huang (2015, Feb) Determination of 4-nitrophenol at Iron Phthalocyanine Decorated Graphene Nanosheets Film Modified Electrode. Int. J. Electrochem. Sci. 10, 1384-1392.

7.    Kun-Li Wang, I-Hao Shih, Sheng-Tung Huang, Hsin-Luen Tsai (2015, Jan). Chemical linkage functions of poly(ether imide)s on the resistive switching memory effects. Organic Electronics, 16, 148-163.

8.    Jiun-An Gu, Veerappan Mani and Sheng-Tung Huang (2015, Feb). Design and synthesis of ultrasensitive off–on fluoride detecting fluorescence probe via autoinductive signal amplification. Analyst, 140, 346-352.

9.    Veerappan Mani, Wen-YungLi, Jiun-An Gu, Chun-Mao Lin, Sheng-Tung Huang (2015, Jan). Electrochemical OFF–ON ratiometric chemodosimeters for the selective and rapid detection of fluoride. Talanta, 131, 121-126.

10.Hsiu-Wen Chien, Ming-Chun Keng, Meng-Jiy Wang, Hsien-Yeh Chen, Sheng-Tung Huang,and Wei-Bor Tsai (2014, Nov). Conjugation of Monocarboxybetaine Molecules on Amino-Poly-p-xylylene Films to Reduce Protein Adsorption and Cell Adhesion. Langmuir, 30, 14257-14262.

11.  Ming-Hui Wang, Jiun-An Gu, Veerappan Mani, Yung-Chao Wu, Yu-Jen Lin, Yu- Ming Chia and Sheng-Tung Huang (2014, Nov). A rapid fluorescence detecting platform: applicable to sense carnitine and chloramphenicol in food samples. RSC Advances, 4, 64112-64118.

12. Veerappan Mani, Rajkumar Devasenathipathy, Shen-Ming Chen, Sheng-Tung Huang, V.S. Vasantha (2014, Aug) Immobilization of glucose oxidase on graphene and cobalt phthalocyanine composite and its application for the determination of glucose. Enzyme and Microbial Technology, 66, 60-66

13.   A. T. Ezhil Vilian, Veerappan Mani, Shen-Ming Chen, Bose Dinesh, and Sheng-Tung Huang, (2014, Sept) The Immobilization of Glucose Oxidase at Manganese Dioxide Particles-Decorated Reduced Graphene Oxide Sheets for the Fabrication of a Glucose Biosensor. Industrial & Engineering Chemistry Research, 53, 15582-15589

14.   Jiun-An Gu, Yu-Jen Lin, Yu-Ming Chia, Hsin-Yi Lin, Sheng-Tung Huang (2013, Apr). Colorimetric and bare-eye determination of fluoride using goldnanoparticle agglomeration probes. Microchim Acta,, 180, 801-806

15.   Hsiu-Wen Chien, Chih-Chi Tsai, Wei-Bor Tsai, Meng-Jiy Wang, Wei-Hsuan Kuo, Ta-Chin Wei, Sheng-Tung Huang (2013, Jan). Surface conjugation of zwitterionic polymers to inhibit cell adhesion and protein adsorption. Colloids and Surfaces B: Biointerfaces, 107, 152-159.

16.   Chi-Ming Lee, Jiun-An Gu, Tin-Gan Rau, Che-Hsiung Yang, Wei-Chi Yang, Shih-Hao Huang, Feng-Yen Lin, Chun-Mao Lin,  and Sheng-Tung Huang (2013, Sept) Low-Cytotoxic Synthetic Bromorutaecarpine Exhibits Anti-Inflammation and Activation of Transient Receptor Potential Vanilloid Type 1 Activities BioMedical Research International, 2013 http://dx.doi.org/10.1155/2013/795095

17.   Meng-Yu Tsai, Ching-Yu Lin, Chi-Hui Huang, Jiun-An Gu, Sheng-Tung Huang, Jiashing Yu and Hsien-Yeh Chen (2012, Sep). Vapor-based synthesis of maleimide-functionalized coating for biointerface engineering. Chemical Communication, 48 (89), 10969-10971 .

18.   Edita Garskait, Guan-Ting Pan, Thomas C.-K. Yang, Sheng-Tung Huang, Aivaras Kareiva (2012, Jun). The study of preparation and photoelectrical properties of chemical bath deposited Zn, Sb and Ni-doped CuInS2 films for hydrogen production. Solar Energy, 86 (9) , 2584-2591..

19.   Hun-Chung Huang, Kun-LiWang, Sheng-Tung Huang, Hsin-Yi Lin, Chun-Mao Lin (2011, Nov). Development of a sensitivelong-wavelength fluorogenic probe for nitroreductase:A new fluorimetric indictor for analyte determination bydehydrogenase-coupled biosensors. Biosensor and bioelectronics, 26 (8) , 3511-3516 .

20.   Szu-Hsu Yu, Yung-Ta Kao, Jui-Yu Wu, Shih-Hao Huang, Sheng-Tung Huang, Chi-Ming Lee, Kur-Ta Cheng, Chun-Mao Lin (2011, Jun). Inhibition of AMPKAssociated Autophagy Enhances Caffeic Acid Phenethyl Ester-Induced Cell Death in C6 Glioma Cells. Planta Medica, 77(9): 907-914.

21.   Tan Yi Lu, Pai-Feng Kao, Chi-Ming Lee, Sheng-Tung Huang, Chun-Mao Lin (2011, Jun). C 60 fullerene nanoparticle prevents β-amyloid peptide induced cytotoxicity in neuro 2A cells. Journal of Food and Drug Analysis , 19 (2) , pp. 151-158+240.

22.   Chi-Ming Lee,Sheng-Tung Huang, Shih-Hao Huang,Hui-Wen Lin, Hsiang-Ping Tsai, Jui-Yu Wu,Chun-Mao Lin, Chien-Tsu Chen, (2011, Feb). C60 fullerenepentoxifylline dyad nanoparticles enhance autophagy to avoid cytotoxic effects caused by the β-amyloid peptide . Nanomedicine: Nanotechnology, Biology and Medicine, 7 (1) , pp. 107-114 .

23.   Hung-Lin Lu, Tina F.-R.Shen, Sheng-Tung Huang, Yung-Liang Tung, Thomas C.-K. Yang (2011, Feb). The degradation of dye sensitized solar cell in the presence of water isotopes. Solar Energy Materials & Solar Cells, 95 (7) , pp. 1624-1629.

24.   Hung-Lin Lu, Yu-Hui Lee, Sheng-Tung Huang,Chaochin Su,Thomas C.-K. Yang (2011, Jan). Influences of water in bis-benzimidazole-derivative electrolyte additives to the degradation of the dye-sensitized solar cells. Solar Energy Materials and Solar Cells, 95 (1), 158-162.

25.   Sheng-Tung Huang, Chun-Jen Teng, Yu-Hui Lee, Jui-Yu Wu, Kun-Li Wang, Chun-Mao Lin (2010, Sep). Design and Synthesis of a Long-wavelength Latent Fluorogenic Substrate for Salicylate Hydroxylase: A useful Fluorimetric indicator for analyte determination by dehydrogenase-coupled biosensors. Analytical Chemistry, 82 (17), 7329-7334 .

26.   Sheng-Tung Huang*, Jia-Liang Jian, Huai-Zu Peng, Kun-Li Wang, Chun-Mao Lin, Chih-Hung Huang, Thomas C.-K. Yang (2010, Jun). Synthesis and optical characterization of new iminocoumarin derivatives. Dyes and Pigments, 86 (1), 6-14.

27.   Sheng-Tung Huang, Der-Jang Liaw,Li-Ga Hsieh,Chin-Chuan Chang,Man-Kit Leung, Kun-Li Wang,Wen-Tung Chen,Kueir-Rarn Lee,Juin-Yih Lai, Li-Hsin Chan,Chin-Ti Chen (2009, Aug). Synthesis and electroluminescent properties of polyfluorene-based conjugated polymers containing bipolar groups. Journal of Polymer Science: Part A: Polymer Chemistry, 47, 6231-6245

28.    Velappan Kandavelu, Hsin-Sian Huang, Jia-Liang Jian, Thomas C.-K. Yang, Kun-Li Wang, Sheng-Tung Huang. (2009, Apr). Novel iminocoumarin dyes as photosensitizers for dye-sensitized solar cell . Solar Energy, 83 (4), 574-581 .

29.   Shwu-Huey Wang, Chien-Shu Chen, Shih-Hao Huang, Szu-Hsu Yu, Zhi-Yang Lai, Sheng-Tung Huang, Chun-Mao Lin (2009, Mar). Hydrophilic Ester-Bearing Chlorogenic Acid Binds to a Novel Domain to Inhibit Xanthine Oxidase . Planta Medica, 75 (11), 1237-1240.

30.   Kun-Li Wang, Sheng-Tung Huang, Li-Ga Hsieh, Guo-Syun Huang (2008, Sep). Synthesis, optical and electrochemical properties of new hyperbranched poly(triphenylamine amide)s . Polymer, 49 (6), 1538-1546 .

31.Sheng-Tung Huang, Chia-Shin Ho, Chun-Mao Lin, Hsu-Wei Fang, Yi-Xiang Peng. (2008, Aug). Development and biological evaluation of C60 fulleropyrolidine-thalidomide dyad as a new anti-inflammation agent. Bioorganic & Medicinal Chemistry, 16 (18),  8619-8626.

32. Sheng-Tung Huang, Kuo-Neng Ting, Kun-Li Wang. (2008, Jul). Development of a long-wavelength fluorescent probe based on quinone–methide-type reaction to detect physiologically significant thiols. Analytica Chimica Acta, 620 (1-2),   120-126 .

33.  Kun-Li Wang, Wun-Tai Liou, Der-Jang Liaw, Sheng-Tung Huang. (2008, Mar). High glass transition and thermal stability of new pyridine-containing polyimides: Effect of protonation on fluorescence . Polymer, 49 (6), 1538- 1546.

34. Sheng-Tung Huang, Yi-Xiang, Kun-Li Wang. (2008, Mar). Synthesis of a new long-wavelength latent fluorimetric indicator for analytes determination in the DT-Diaphorase coupling dehydrogenase assay system . Biosensor and Bioelectronics, 23 (12),  1793-1798 .

35.   Sheng-Tung Huang, Jian-Sheng Liao, Hsu-Wei Fang, Chun-Mao Lin (2008, Jan). Synthesis and anti-inflammation evaluation of new C60 fulleropyrrolidines bearing biologically active xanthine. Bioorganic & Medicinal Chemistry Letters, 18 (1),  99-103

36. Yuan-Ching Chang, Fu-Wei Lee, Chien-Shu Chen, Sheng-Tung Huang, Shin-Hui Tsai, Shih-Hao Huang, Cun-MaoLin* “ Struture-activiy relationship of C6-C3 phenylpropanoids on xanthine oxidase-inhibiting and free radical-scavenging activities” Free Radical Biology & Medicine, 2007, 43, 1541-1555

37.Kou-gea Shyu, Sheng-Tung Huang, Hsien-Shou Kuo, Wen-Pin Cheng, Yuh-Ling Lin* “ Antitumor activity of a novel bis-aziridinylnapthoquinone (AZ4) mediating cell cycle arrest apoptosis in non-small cell lung cancer cell line NCI-H460” Acta Pharmacologica Sinica, 2007, 28, 559-566

38.   Chun-Mao Lin, Sheng-Tung Huang, Fu-Wei Lee, Hsien-Saw Kuo, Mei-Hsiang Lin* “6-Acyl-4-aryl/alkyl-5,7-dihydroxycoumarins as anti-inflammatory agents” Bioorganic & Medicinal Chemistry, 2006, 14, 4402-4409

39.   Sheng-Tung Huang*, Yuh-Ling Lin “New Latent Fluorophore for DT-Diaphorase” Organic Letters, 2006, 8, 265-268

40.   Chun-Mao Lin, Sheng-Tung Huang, Yu-Chih Liang, Mei-Shan Lin, Chwen-Ming, Shih, Yuang-Ching Chang, Tzong-Yueh Chen, Chien-Tsu Chen* “Isovitexin suppresses lipopolysaccharide-mediated inducible nitric oxide synthase through inhibition of NF-kappa B in mouse macrophages” Planta Medica, 2005, 71, 748-753

41.   Sheng-Tung Huang, Chien-Tsu Chen, Kur-Ta Cheng, Shih-Hao Huang, Been-Huang Chiang, Leng-Fang Wang, Hsien-Saw Huo, Chun-Mao Lin* “Inhibitory Effects of a rice hull constituent on tumor necrosis factor, prostaglandin E2, and cyclooxygenase-2 production in lipopolysaccharide-activated mouse macrophages” Annals of the New York of Academy of Sciences, 2005, 1042, 387-395

42.   Sheng-Tung Huang, Tsai, H. D., Kuo, H. S., Yang, Y. P., Peng, Y. C., Lin, Y. L. (2004) A novel bis-aziridinylnaphthoquinone with anti-solid tumor activity in which caused apoptosis is associated with altered expression of bcl-2 protein   ChemBioChem, 2004, 5, 797-803

43.   Cheng, K.-T.*, Rajasekhar, D., Sheng-Tung Huang, Hsu, F.-L., Subbaraju, G.V. Revised structure for spatozoate, a metabolite of Spatoglossum variabile Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003, 42 (5), 1190-1192

44.   Sheng-Tung Huang, Kuo, H. S., Lin, C. M., Tsai, H. D., Peng, Y. C., Chen, C. T. , Lin, Y. L. Synthesis and Biological Evaluation of Novel Bis-Aziridinylnaphthoquinone Derivatives Oncology- Research, 2003, 13, 199-204

45.   Lin, Y. L., Kuo, H. S. Wang, Y. W., Sheng-Tung Huang.* Efficient Entry to 1-benzoxepine ring skeleton via Tandem SN2/Wittig Reaction.  Total Synthesis of NADH:Ubiquinone Oxidoreductase (Complex I) Antagonist Pterulinic Acid Tetrahedron, 2003, 59, 1277-1281

46.   Sheng-Tung Huang, Kuo, H. S., Hsiao, C. L., Lin, Y. L. Efficient Synthesis of ‘Redox-Switched’ Naphthoquinone Thiol-Crown Ethers and Their Biological Activity Evaluation. Bioorganic & Medicinal Chemistry, 2002, 10,1947-1952

47.   Sheng-Tung Huang*, Kuo,H.S. and Chen. C.T., (2001) Total Synthesis of NADH:Ubiquinone Oxidoreductase (Complex I) Antagonist Pterulone and Its Derivative. Tetrahedron Lett., 2001,  42 7473-7475.

48.   Sheng-Tung Huang and Gordon, M. D.,Total Synthesis of Endothelin-Converting Enzyme Antagonist WS75624B. Tetrahedron Lett. 1998, 39, 9335.

49.   Sheng-Tung Huang.; Choi, W. E.; Bloom, C. R.; Leuenberger, M.; Dunn, M. F. Carboxylate Ions Are Strong Allosteric Ligands for the HisB10Sites of the R-State Insulin Hexamer. Biochemistry, 1997, 36, 9878.

50.   Eldin, S. E.; Digits, A. Sheng-Tung Huang.; Jencks, W. P.,. Lifetime of An Aliphatic Iminium Ion in Aqueous Solution. J. Am. Chem. Soc., 1995, 117, 6631.

51.   Bloom, C. R.; Choi,W. E.; Brzovic P. S.; Ha, J. J.; Sheng-Tung Huang; Kaarsholm, N. C.; Dunn, M. F., Ligand Binding to Wild-type and E-B13Q Mutant Insulin: A Three-state Allosteric Model System Showing Half-site Reactivity.  J. Mol. Biol., 1995, 245, 324



Patents:

 

1.   Sheng-Tung Huang and Yi-Xiang Peng, Latent Fluorimetric Indicator for Biological Analytes Determination and the Preparation Method Thereof, United States of America, US 8153811 2012/4/12

2.   Sheng-Tung Huang and Chung-Kuang Yang, Electrolyte Additive of Dye-Sensitized Solar Cell and Method of Making the Same, United States of America, US 8410283 2013/4/2

3.   Sheng-Tung Huang, Salicylic Acid Derivatives with Fluorophores and Methods of Making and Using the Same, United States of America US 8691980 2014/4/8



Conferences


1. Jiun-An Gu and Sheng-Tung Huang* (2010) A Rapid Colorimetric Visualization Assay of Floride Ion by Using Gold Nanoparticle 10th International Conference on Materials Chemistry (MC10) University of Manchester, United Kingdom July 4th to 7th.

2. Hun-Chung Huang and Sheng-Tung Huang* (2009) Novel Long-Wavelength Latent Fluorophore for Real Time Monitoring Nitroreductase Activities 2009中國化學會年會 義守大學燕巢分部 124126

3. Yu-Hui Li, Chun-Jen Teng, and Sheng-Tung Huang* (2009) Characterization and Application of New Salicylate Hydroxylase Targeted Fluorophore  2009中國化學會年會 義守大學燕巢分部 124126