國立臺北科技大學 組織工程與動物細胞培養實驗室 (生物科技館 402)

主持人 林忻怡 教授

 

研究方向 Research Interests

 

在組織修復和細胞/藥物輸送領域中,本實驗室研究主軸為開發新的生物材料和新的方法來建構細胞支架和藥物載體。

目前實驗室以化學修飾的方法改質天然高分子聚合物如幾丁聚醣,海藻酸鈉,膠原蛋白等,使它們能夠按照不同的需求、不同的應用而擁有不同的性質。例如,我們需要調整材料的機械性能,使他們能夠填補不同的組織缺損,或我們要改變材料的膨脹度/親水性,使成品有不同的藥物釋放效率與結構穩定性,或我們可以在材料上接枝特殊官能基改變材料生物相容性,以使其更利/不利於細胞附著。

本實驗室使用三維繪圖系統和靜電電紡方式製造不同類型的細胞支架,所做出的高分子支架具高孔隙度。動物細胞、奈米磁珠、和攜帶藥物的微粒可被封裝在支架材料中,以提高支架的功能性。製造出之材料/支架可經由各式分析設備和細胞培養測量其物理性質與生物相容性。

 

Our lab focuses on the development of new biomaterials and new ways of constructing cell scaffold and drug carrier for purpose of tissue repair and cell/drug delivery.

Currently we take natural polymers such as chitosan, alginate, collagen etc. and chemically modify them to tailor their properties for different applications. For example, we want to adjust the materials’ mechanical properties so they can be used in different tissue defects, or to change the swelling/wettability of a material so it will have a different drug release efficacy or material stability, or to add a functional group to a material in order to make it more/less favorable for cell attachment.

This lab uses the above mentioned materials and manufactures different kinds of cell scaffolds, mostly with a lot of pores, by three-dimensional plotting and electrospinning. Cells and/or microbeads that contain drugs or magnetic particles may be encapsulated in the scaffolding material to enhance the performance of the scaffold. We subsequently test their physical properties and biological compatibility with different analytical equipments and cell culture.

 

學歷 Education

 

2002- 博士  美國密西西比大學生物醫學工程

2002 Ph.D. Biomedical Engineering, The Mississippi State University, MS, USA

1999- 碩士  美國賓州州立大學生物工程

1999 M.S. Bioengineering, The Pennsylvania State University, PA, USA

1996- 學士  國立台灣大學化學工程學士

1996 B.S. Chemical Engineering, the National Taiwan University, Taiwan  

 

經歷 Experience

 

1032- 迄今      國立台北科技大學 生化與生醫工程研究所 教授

Feb 2014- current      Professor, Institute of Biochemical and Biomedical Engineering, National Taipei University of Technology, Taiwan

992-1031  國立台北科技大學 生物科技研究所 副教授

Feb 2010- Jan 2014     Associate Professor, Institute of Biotechnology, National Taipei University of Technology, Taiwan 

958- 991   國立台北科技大學 生物科技研究所 助理教授

Aug 2006 – Jan 2010    Assistant Professor, Institute of Biotechnology, National Taipei University of Technology

9210- 948  美國內部拉斯加大學 化學工程系 博士後研究員

Oct 2003 –Aug 2005     Postdoctoral Research Scientist, Department of Chemical Engineering, University of Nebraska-Lincoln, NE

906- 908   人造皮膚生醫公司 生醫材料開發部門研究助理

Jun 2001- Aug 2001     Research assistant, Biomaterials division, Ortec International (now Forticell Bioscience), New York

 

執行計畫 (Projects):

 

國科會(National Science Council95/9/1~95/7/31- 電磁波對成骨組織工程及人體免疫系統之影響 (Effects of Electromagnetic Field on Bone Tissue Engineering and Immune System)

亞東紀念醫院 (Far East Memorial Hospital) 96/01/01~96/12/31- 低頻電磁波對軟骨組織修復之影響 (Effects of Low Frequency Electromagnetic Field on Cartilage Regeneration)  

國科會(National Science Council96/8/1~97/7/31- 以持續性釋放雷公藤萃取物之藥物傳送系統治療類風濕性關節炎(I) (Controlled Release of Tripterygium wilfordii Hook F Extract as Potential Therapy for Patients with Rheumatoid Arthritis)

國科會(National Science Council97/8/1~98/7/31- 以生物材料塗佈金屬表面以釋放新穎抗發炎藥物 (Metal Implant Coatings as Carriers to Deliver Two Novel Anti-inflammatory Compounds)

98年度 教育部大學跨學門科學人才培育銜接計畫 (98/1/1-98/12/31)-材料表面與細胞組織交互作用課程計畫 

99年度 馬偕醫院-台北科技大學 合作計畫- 以熔融沉積法 (Fused Deposition Modeling) 製造水凝膠敷材-體外測試與動物試驗

國科會(National Science Council 99-2221-E-027-039-99/8/1~100/7/31- 製作雙層複合式支架以修復全層皮膚組織 (Making A Bi-layer Composite Scaffold for Full Thickness Skin Repair).

100年度 馬偕紀念醫院-台北科技大學 合作計畫- 製作雙層皮膚支架組織以達高效能全層皮膚傷口修復

100年度 台北醫學大學-台北科技大學 合作計畫-以立體印製方式(3D Plotting)製造固定孔徑大小與孔洞聯繫度之水凝膠骨材

國科會(National Science Council NSC 100-2221-E-027-026100/8/1~101/7/31- 以立體繪製技術製造纖維內含細胞且孔洞互通之幾丁聚醣水凝膠支架以修復骨頭組織 (Using 3D Plotting Technology to Make Fibrous Scaffolds with Interconnected Pores and Living Cells in the Fibers for Bone Repair)

101年度 台北科技大學暨馬偕紀念醫院合作計畫- 以立體繪製技術製造纖維內含皮膚細胞之褐藻酸水凝膠支架 NTUT-MMH-101-14 (101/1/30 ~ 101/12/31)

101年度 台北科技大學台北醫學大學合作計畫-動態細胞培養系統對抗發炎藥物輸送效率及骨組織修復之影響 NTUT-TMU-101-08 (101/1/30 ~ 101/12/31)

國科會(National Science Council NSC 101-2221-E-027-140101/8/1~102/7/31- 以一型膠原蛋白奈米纖維修飾鈦合金表面來提升金屬表面之骨傳導以加強骨組織與植入物之嵌合度

102年度 台北科技大學暨馬偕紀念醫院合作計畫- 以膠原蛋白奈米纖維修飾不鏽鋼植入物表面 NTUT- MMH- 10206 (102/1/1~ 102/12/31)

 

國科會(National Science Council NSC102-2221-E-027-068-102/08/01~103/07/31 探討細胞與周圍材料之相互作用如何影響細胞對外來刺激之反應

科技部 (MOST 103-2221-E-027 -095 -) 103/08/01 104/07/31 幾丁聚醣纖維中包覆褐藻酸同軸纖維/微粒以改善幾丁聚醣支架之細胞與

科技部 (MOST 104-2221-E-027-101-) 104-08-01~ 105-07-31 以化學方法修飾幾丁聚醣製造可抗菌與抗發炎之細胞支架以提高支架之組織修復效果

科技部 (MOST 105-2221-E-027-117-) 105-08-01~ 106-07-31 結合抗菌大孔洞奈米纖維及3D成型多孔洞支架製作複合式細胞共培養系統提升皮膚修復品質

 

研究成果目錄 Publications

 

期刊論文 (Peer-reviewed Journal Publications)

Lin HY* and Peng ZX. Nanofibers Grafted on Titanium Alloy: The Effects of Fiber Alignment and Density on Osteoblast Mineralization. J Mater Sci Mater Med 2017, 28(9):140. (SCI/EI, IF=2.325, 29/77 Eng, Biomed)

Lin HY*, Tsai WC, Chang SH. Collagen-PVA aligned nanofiber on collagen sponge as bi-layered scaffold for surface cartilage repair. J Biomater Sci Polym Ed. 2017 May;28(7):664-678. (SCI/EI, IF=1.733, ranking in Polymer Science= 28/85= 32.9%)

I-Hsin Liu, Shih-Hsin Chang and Hsin-Yi Lin*. Chitosan-based hydrogel tissue scaffolds made by 3D plotting promotes osteoblast proliferation and mineralization. Biomedical Materials 2015, 10(3):035004. (SCI/EI, IF=2.174, ranking in Engineering: Biomedical= 29/79=36%)      

Hsin-Yi Lin*, Shin-Hung Chen, Shih-Hsin Chang, Sheng-Tung Huang. Tri-layered chitosan scaffold as a potential skin substitute. Journal of Biomaterials Science Polymer Ed. 2015, 26 (13): 855-67. (SCI/EI, IF=1.648, ranking in Polymer Science= 42/82= 51.2%)

Hsin-Yi Lin*, Chih-Wei Peng, Wei-Wen Wu. Fibrous hydrogel scaffolds with cells embedded in the fibers as a potential tissue scaffold for skin repair. Journal of Materials Science: Materials in Medicine Jan 2014, 25(1):259-269. (SCI/EI, IF= 2.141, ranking in Engineering: Biomedical= 30/79=37%)

Hsin-Yi Lin* and Jing-Huei Chen. Study of Chitosan-based Coatings on Ti-6Al-4V and Their Effects on Osteoblast Phenotype Expression and Differentiation. Carbohydrate Polymers 2013, 97(2), 618–626. (SCI/EI, IF= 3.479, ranking in Polymer Science= 13/83=15%) 

Hsin-Yi Lin*,Yu-Jen Kuo, Shih-Hsin Chang, Tsung-Sheng Ni. Characterization of electrospun nanofiber matrices made of collagen blends as potential skin substitutes. Biomedical Materials Feb 22, 2013. 8(2):025009. (SCI IF=2.158, Engineering, Biomedical: 24/72=33%)

Hsin-Yi Lin*, Hsin-Hung Chen, Shih-Hsin Chang, Tsung-Sheng Ni. Pectin-Chitosan-PVA Nanofibrous Scaffold Made by Electrospinning and Its Potential Use As A Skin Tissue Scaffold. Journal of Biomaterials Science Polymer Edition 2012, p1-15 (SCI IF=1.842, Engineering, Biomedical 30/70=42%)

Peng, C.-W., Lin, H.-Y.*, Wang, H.-W., Wu, W.-W. The influence of operating parameters on the drug release and anti-bacterial performances of alginate wound dressings prepared by three-dimensional plotting. Materials Science and Engineering C , 32(8), 1 December 2012, p2491-2500 (SCI/EI, IF= 2.686, Materials Science-Biomaterials 10/25)

Hsin-Yi Lin* and Hsin-Wei Wang. The influence of operating parameters on the drug release and antibacterial performances of alginate fibrous dressings prepared by wet spinning. Biomatter 2012, 2:4, p1–8

Hsin-Yi Lin and Chih-Tsung Yeh. Genipin-crosslinked chitosan scaffolds and its efficacy in releasing anti-inflammatory medicine. Bio-Medical Materials and Engineering 22 (2012) 321–332 (SCI, EI, IF= 1.225)

Hsin-Yi Lin* and Yu-Jen Lin. In Vitro Effects of Low Frequency Electromagnetic Fields on Osteoblasts Proliferation and Maturation In An Inflammatory Environment. Bioelectromagnetics, 2011, 32, 552-560.

Shih-Hsin Chang, Yi-Wei Hsiao, Hsin-Yi Lin*. Low Frequency Electromagnetic Field Exposure Accelerates Chondrocytic Phenotype Expression on Chitosan Substrate. Orthopedics 2011 34(1), 20.

Hsin-Yi Lin*, Chih-Tsung Yeh. Controlled Release of Pentoxifylline From Porous Chitosan-Pectin Scaffolds. Drug Delivery 2010 Jul;17(5):313-21. (SCI impact factor 1.550) (PHARMACOLOGY & PHARMACY 169/236=71%)

Hsin-Yi Lin*, Chih-Tsung Yeh. Alginate-crosslinked chitosan scaffolds as pentoxifylline delivery carriers. J Mater Sci: Mater Med 2010 May;21(5):1611-20. (SCI impact factor 1.955) (Materials Science: Biomaterials 14/25=56%)

Hsin-Yi Lin* and Sin-Yang Ciou. Modifications of Alginate-based Scaffolds and Characterizations of Their Pentoxifylline Release Properties. Carbohydrate Polymers 2010, 80 (2), 575-581. (SCI impact factor 3.167)(Polymer Science, 12/77 (15%))

Hsin-Yi Lin* and Ko-Hsien Lu. Repairing Large Bone Fractures with Low Frequency Electromagnetic Field. J Orthop Res, 2010 Feb;28(2):265-70. (SCI impact factor (Orthopedics 3.112, 4/56 (8%))

Chih-Hung Chang, Siow-Tung Loo, Hsuan-Liang Liu, Hsu-Wei Fang, Hsin-Yi Lin*. “Can Low Frequency Electromagnetic Field Help Cartilage Tissue Engineering?” Journal of Biomedical Materials Research: Part A. 2010 Mar 1;92(3):843-51. (SCI impact factor: 2.816) (ENGINEERING, BIOMEDICAL 14/59=23%)

Hsuan-Liang Liu*, Yi-Fan Liu, Jian-Hua Zhao, Chi-Hung Huang, Hsin-Yi Lin, Hsu-Wei Fang, Yih Ho, Wei-Bor Tsai, and Wen-Yih Chen, “Molecular Dynamics Simulations to Investigate the Aggregation Behaviors of the Ab(17-42) Oligomers” Journal of Biomolecular Structure and Dynamics 2009 26 (4), pp. 481-490) (SCI, Impact factor: 1.559)

Jian-Hua Zhao, Ching-Tao Yang, Josephine W. Wu, Wei-Bor Tsai, Hsin-Yi Lin, Hsu-Wei Fang, Yih Ho, and Hsuan-Liang Liu*, “RING Domains Functioning as E3 Ligases Reveal Distinct Structural Features: A Molecular Dynamics Simulation Study”, Journal of Biomolecular Structure & Dynamics, 26 (1), 65-74 (August 2008) (SCI, impact factor: 1.407)

Hsin-Yi Lin*, Bonnie Bowers, John T. Wolan, Zhou Cai, Joel D. Bumgardner. “Metallurgical, surface and corrosion analysis of Ni-Cr dental casting alloys before and after porcelain firing.” Dental Materials 2008 Mar; 24(3): 378-85 (SCI, Impact factor: 2.882) (DENTISTRY, ORAL SURGERY & MEDICINE 7/64=11%)

Chih-Hung Chang, Hsin-Yi Lin, Hsu-Wei Fang, Show-Tung Loo, Shi-Chieh Hung, Yi-Ching Ho, Chia-chun Chen, Feng-Huei Lin*, Hwa-Chang Liu*, “Chondrogenesis from Immortalized Human Mesenchymal Stem cells: Comaprison between Collagen Gel and Pellet Culture Methods” Artificial Organs 2008 Jul; 32(7):561-6 (SCI, Impact factor: 1.903)

Hsu-Wei Fang*, Meng-Lin Shih, Jian-Hua Zhao, Huei-Ting Huang, Hsin-Yi Lin, Hsuan-Liang Liu, Chih-Hung Chang, Charng-Bin Yang, Hwa-Chang Liu, “Association of polyethylene friction and thermal unfolding of interfacial albumin molecules” Applied Surface Science, 253, pp. 6896-6904, 2007 (SCI, Impact factor: 1.436)

Jian-Hua Zhao, Hsuan-Liang Liu, Hsin-Yi Lin, Chih-Hung Huang, Hsu-Wei Fang, and Shau-Wei Tsai, “Semiempirical molecular orbital studies of the acylation step in the lipase-catalyzed ester hydrolysis” Journal of the Chinese Chemical Society , 54 (4), 835-842 (Accepted in Aug. 2007) (SCI, Impact factor: 0.593)

Hsuan-Liang Liu*, Fu-Chiang Yang, Hsin-Yi Lin, Chi-Hung Huang, Hsu-Wei Fang, Wei-Bor Tsai, Yung-Chu Cheng, “Artificial neural network to predict the growth of the indigenous Acidthiobacillus thiooxidansChemical Engineering Journal 2008;137(2):231-7 (SCI, Impact factor: 1.594)

Hsuan-Liang Liu*, Yuan-Min Lin, Jian-Hua Zhao, Man-Ching Hsieh, Hsin-Yi Lin, Chi-Hung Huang, Hsu-Wei Fang, Yih Ho, and Wen-Yih Chen, “Molecular Dynamics Simulations of Human Cystatin C and Its L68Q Varient to Investigate the Domain Swapping Mechanism” Journal of Biomolecular Structure & Dynamics, 25 (2), 135-144, 2007 (SCI, Impact factor: 1.528)

Hsuan-Liang Liu*, Ching-Tao Yang, Jian-Hua Zhao, Chi-Hung Huang, Hsin-Yi Lin, Hsu-Wei Fang, Yih Ho, Wei-Bor Tsai, “Molecular Dynamics Simulations to Investigate the Effects of Zinc Ions on the Structural Stability of the c-Cbl RING Domain” Biotechnology Progress, 23 (5), 1231-1238, 2007 (SCI, Impact factor: 1.559)

Jian-Hua Zhao, Hsuan-Liang Liu*, Hsin-Yi Lin, Chi-Hung Huang, Hsu-Wei Fang, Yih Ho, Wei-Bor Tsai, Wen-Yih Chen. “Chemical chaperone and inhibitor discovery: potential treatments for protein conformational diseases” Perspectives in Medicinal Chemistry, 1, 39-48, 2007.

Subramanian A, * Lin HY ."Crosslinked chitosan: Its physical properties and the effects of matrix stiffness on chondrocyte cell morphology and proliferation." J Biomed Mater Res , 2005, 75(3): 742-53. (SCI, Impact factor: 2.497)

Anuradha Subramanian, David Vu, Gustavo F. Larsen, *Hsin-Yi Lin, "Preparation and evaluation of the electrospun chitosan/PEO fibers for potential applications in cartilage tissue engineering.” J. Biomater. Sci. Polymer Ed, 2005, 16(7):861-73. (SCI, Impact factor: 1.607)

A. Subramanian, H. Lin , G. Larsen, and D. Vu, "Synthesis and evaluation of scaffolds prepared from chitosan fibers for potential use in cartilage tissue engineering." Biomed. Sci. Instrum. , 2004, 40, 117. (EI)

Hsin-Yi Lin and Joel D Bumgardner. "In vitro  biocorrosion of Co-Cr-Mo implant alloy by macrophage cells." * J Ortho Res 2004, 22(6): 1231-6. (SCI, Impact factor: 2.784)

*Hsin-Yi Lin  and Joel D. Bumgardner. "In vitro biocorrosion of Ti6Al4V implant alloy by a mouse macrophage cell line." J Biomed Mater Res 2004, 68A :717-724. (SCI, Impact factor: 2.497)

*Hsin-Yi Lin and Joel D. Bumgardner. "Changes in the surface oxide composition of Co-Cr-Mo implant alloy by macrophage cells and their released reactive chemical species." Biomaterials 2004; 25(7-8): 1233-8. (SCI, Impact factor: 5.196)

*Hsin-Yi Lin  and Joel D. Bumgardner. "Changes in surface composition of the Ti-6Al-4V implant alloy by cultured macrophage cells." App Surf Sci  2004, 225: 21-28. (SCI, Impact factor: 1.436)

Parker, SH, Lin, HL , Zardiackas, LD and Bumgardner, JD. "Influence of Macrophage Cells on 316L Stainless Steel Corrosion." Stainless Steels for Medical and Surgical Applications , ASTM STP 1438, ASTM International, 2003.  

*Lin, HY ; Bianccucci, BA; Deutsch, S; Fontaine, AA; Tarbell, JM. "Observation and quantification of gas bubble formation on a mechanical heart valve." J Biomech Eng. , 2000, 122(4), 304. (EI) 

 

研討會論文 (Conference Publications)

 

國際研討會論文 International Conferences

Huei-Syuan Lin and Hsin-Yi Lin*. Production of 3D porous alginate with rapid prototype binding electrospun chitosan/PVA nano-fibrous composite materials. 2016 Tissue engineering and regnerative medicine international society (TERMIS), 2016-09-03~06, Tamsui, Taipei, Taiwan.

Bo-Chun Li and Hsin-Yi Lin*. Cyclic stretch on the growth and morphology of fibroblasts embedded in high alpha-l-guluronic alginate hydrogel. 2016 Tissue engineering and regnerative medicine international society (TERMIS), 2016-09-03~06, Tamsui, Taipei, Taiwan.

Wei-Shang Chiou and Hsin-Yi Lin*. Ti6Al4V titanium alloy surface coating of chemically modified chitosan can be manufactured with antibacterial effect of on osteoblast culture. 2016 Tissue engineering and regnerative medicine international society (TERMIS), 2016-09-03~06, Tamsui, Taipei, Taiwan.

Hsin-Yi Lin* and Wei-Shiang Chiou. Modify chitosan-coated Ti6Al4V with antimicrobial peptide to reduce infection and promote osteointegration on Ti6Al4V surface. 2nd Global Conference of Biomedical Engineering, August 17-19, 2016.

Hsin-Yi Lin* and Tsang-Wen Chang. Chitosan-coated alginate tissue scaffold constructed by three dimensional plotting technique used for drug and cell delivery. 10th World Biomaterials Congress, May 17-22, 2016, Quebec, Canada. 

Hsin-Yi Lin* and Wan-Jung Lo. Chitosan film embedded with alginate particles to improve chitosan film cell and drug delivery and efficiency. 2015 Biomaterials International. June 1-5, 2015, Kenting, Taiwan.

Hsin-Yi Lin* and Tsang-Wen Chang. Chitosan coating alginate fiber for improving the cell in fiber and promoting the efficiency for drug release. 2015 Biomaterials International. June 1-5, 2015, Kenting, Taiwan.        

Hsin-Yi Lin* and Min-Che Wu. Effects of cyclic stretching on fibroblasts embedded in alginate microfiber. 7th World Congress of Preventative and Regenerative Medicine, Nov 4-7, 2014. Chientan Youth Activity Center, Taipei, Taiwan.

Hsin-Yi Lin* and Zhao-Xiang Peng. Modification of surface of Ti6Al4V alloy with collagen nanofiber for culture of osteoblast. 7th World Congress of Preventative and Regenerative Medicine, Nov 4-7, 2014. Chientan Youth Activity Center, Taipei, Taiwan.

Hsin-Yi Lin* and Yen-Ying Li. In vitro studies of fibroblasts embedded in hydrogelic fibers made of RGD modified alginate. 7th World Congress of Preventative and Regenerative Medicine, Nov 4-7, 2014. Chientan Youth Activity Center, Taipei, Taiwan.

Hsin-Yi Lin* and Min-Che Wu. Effects of vibration on cultured fibroblasts embedded in 3D fibrous with rapid prototyping technique. 12th International hydrocolloids Conference, May 5-9, 2014. Howard International Conference Center, Taipei, Taiwan.

Hsin-Yi Lin* and Zhao-Xiang Peng. The study of fabrication a porous collagen scaffold by electrospinning on surface modification Ti6Al4V titanium alloy. 12th International hydrocolloids Conference, May 5-9, 2014. Howard International Conference Center, Taipei, Taiwan.

Hsin-Yi Lin* and Yen-Ying Li. Use RGD peptide modified with 3D porous alginate scaffold to improve cell adhesion. 12th International hydrocolloids Conference, May 5-9, 2014. Howard International Conference Center, Taipei, Taiwan.

Hsin-Yi Lin*, Hsin-Hung Chen. Preparation of a Bi-layer Porous Skin Scaffold Fabricated via electrospinning and Freeze-drying techniques. The 2nd International Symposium of Materials and Regenerative Medicine. August 29-31, 2012. Taipei Medical University, Taipei, Taiwan.

Hsin-Yi Lin*, Wei-Wen Wu. Cells Embedded in Fibers in Porous Scaffold through 3D Plotting Fabrication to Repair Skin. The 2nd International Symposium of Materials and Regenerative Medicine. August 29-31, 2012. Taipei Medical University, Taipei, Taiwan.

Hsin-Yi Lin*, I-Hsin Liu. Using Rapid Prototyping System to Produce Chitosan Composite 3D Scaffolds for Bone tissue Repair. The 2nd International Symposium of Materials and Regenerative Medicine. August 29-31, 2012. Taipei Medical University, Taipei, Taiwan.

Hsin-Yi Lin*, Min-Chun Kan. Electrospun Pectin/Chitosan/PVA Nanofibrous Scaffolds As Skin Wound Dressings. Abstract accepted by 2011 Society for Biomaterials Annual Meeting and Exposition from April 13-16, 2011, at Orlando, FL, USA.

Hsin-Yi Lin*, Min-Chun Kan. Electrospun Pectin/Chitosan/PVA Nanofibrous Membrane As Skin Wound Dressing. 2010 International Symposium of Materials on Regenerative Medicine. November 3-5, 2010, International Convention Center, National Health Research Institutes, Taiwan.

Hsin-Yi Lin*, Yu-Hsin Wang. Alginate Skin Wound Dressing Manufactured by Rapid Prototyping Technique. 2010 Society for Biomaterials Annual Meeting and Exposition from April 21-23, 2010, at Seattle, Washington, USA.

Chin-Tsung Yeh and Hsin-Yi Lin. Preparation of tissue engineering scaffolds suitable for drug delivery application. Tissue Engineering and Regenerative Medicine International Society- World Congress 2009. Seoul, Korea. August 31-September 3, 2009.

Sin-Yang Ciou, Hsin-Yi Lin*. The Effects of Controlled Release of Pentoxifylline from Crosslinked Chitosan Porous Scaffolds in Suppressing Inflammatory Reactions. The 11th International Conference on Chitin and Chitosan. Sept. 6 ~ 9, 2009. National Taiwan University of Science and Technology (NTUST), Taipei, p113.

Ko-Hsien Lu, Hsin-Yi Lin*. “Effects of low frequency electromagnetic field on osteoblasts growing on chitosan scaffolds.” 2008 Annual Conference of Tissue Engineering and Regenerative Medicine International Society- Asian Pacific Region (2008 TERMIS - AP)Chien-Tan Overseas Youth Activity Center Taipei, TaiwanNovember 6 – 8, 2008收錄於研討會手冊107

 

國內研討會論文 National Conferences

Hsin-Yi Lin*. Ionically crosslinked microfibrous alginate scaffolds for improved drug delivery and cell attachment. 17th Conference on Chitin, Chitosan, and other Biomaterials. Invited speaker. Tamkang University, Taipei, Taiwan. 2017/6/2~3.

Huei-Shyan Lin and Hsin-Yi Lin*. Making bi-layered composite scaffold with 3D plotted alginate hydrogel and chitosan PVA nanofibers for tissue repair. 2016 台灣化學工程學會63周年慶祝大會暨科技部化工學門成果發表會. 105/11/25~26. 國立中央大學,化工與材料工程系, Taiyuan, Taiwan.

Bo-Chun Li and Hsin-Yi Lin*. Effects of cyclic stretching and the growth and morphology of fibroblasts embedded in high L-guluronic alginate hydrogel. 2016 台灣化學工程學會63周年慶祝大會暨科技部化工學門成果發表會. 105/11/25~26. 國立中央大學,化工與材料工程系, Taiyuan, Taiwan.

Co-axial fiber and beads made of alginate embedded in chitosan fibers to make tissue scaffolds with improved cell/drug delivery capacity. 國立臺北科技大學暨學術合作夥伴研究成果聯合發表會。國立臺北科技大學綜合科館,10561日。收錄於研討會手冊P39-40

Yu-Jen Lin (林佑任), Hsin-Yi Lin (林忻怡). The effect of low frequency electromagnetic fields on stimulating inflammatory reaction and bone tissue engineering.14th Conference on Biochemical Engineering (2009). 台中中興大學,會議日期: June 5-6, 2009。收錄於研討會手冊188

Hsin-Yi Lin*, Lu Ko-Hsien, Xiao Yi-Wei, “The effects of low frequency electromagnetic field on bone tissue engineering.” 發表於2007幾丁質與幾丁聚糖年會暨研討會,中壢萬能大學,台灣.收錄於研討會手冊524-527 (NSC-95-2218-E-027-022).會議日期:May 25, 2007

林忻怡*, 葉志宗. “幾丁聚糖與褐藻酸製成多孔性藥物載體之物理性質探討,發表於2008幾丁質與幾丁聚糖研討會,台南成功大學,台灣.收錄於研討會手冊103-106 (NSC-96-2221-E-027-110). 會議日期:May 16, 2008

張志宏,劉宣良,方旭偉,林忻怡*. “Can Low Frequency Electromagnetic Field Help Cartilage Tissue Engineering?” 2008中華民國骨科醫學年會,林口長庚醫院,台灣.會議日期: October 25, 2008. 收錄於研討會手冊110

 

研究方向 (Research Interests)

 

可生物分解高分子生醫材料 (Biodegradable polymeric implant materials including chitosan and collagen)

骨科及皮膚組織工程研發 (Orthopedic and skin tissue engineering)

藥物傳送 (Drug delivery)

動物細胞培養 (Mammalian cell culture and characterization)