超臨界流體與藥物結晶技術研究室

Supercritical Fluids and Pharmaceutical

Crystallization Technology Lab.

 

 

蘇至善(Chie-Shaan Su)助理教授

 聯絡方式  
 辦公室: 化工館202 (02)2771-2171#2532
  實驗室: 化工館401A(02)2771-2171#2579   
  E-mail: cssu@ntut.edu.tw  
 
 學歷
 國立台灣大學             化學工程系       博士             2003.9-2007.10 
 國立台灣大學             化學工程系       碩士             2001.9-2003.7 
 國立台灣科技大學         化學工程系       學士             1999.9-2001.6
 國立台北工業專科學校     化學工程科       專科             1994.9-1999.6
 
 經歷
 台灣東洋藥品股份有限公司 製劑研發處       副研究員   2010.12-2011.7
 味全食品工業股份有限公司 製程設備技術中心 研究員      2010.9-2010.12   
 台灣神隆股份有限公司     製程技術處       資深工程師  2008.10-2010.8
 
目前研究主題
1.利用超臨界反溶劑法進行原料藥物性控制與製劑設計之研發
2.利用超臨界快速膨脹法進行藥物微粒化之熱力學研究與實驗探討
3.離子液體與符合製藥法規溶劑之二成分混合物熱物性質測定
4.以溶液模式進行藥物固體於超臨界二氧化碳中之溶解度計算與預測
5.利用超音波結晶技術進行原料藥物性控制之研發
6.利用超臨界流體技術進行生醫材料之製備 
 
研究主軸
 
實驗室基礎課程
1.  文獻搜尋與專利檢索
2. 結晶技術概論
3. 藥物多晶型概論
4. 超臨界流體技術
5. 儀器分析概論
6. 超臨界流體技術相關熱力學性質計算與程式模擬
7. 原料藥產業概論
 
研究成果

1.  SCI/EI期刊論文

[1]

C. S. Su, Y. P. Chen, Recrystallization of salicylamide using a batch supercritical anti-solvent process, Chem. Eng. Technol. 28 (2005) 1177-1181

[2]

C. S. Su, Y. P. Chen, Correlation for the solubilities of pharmaceutical compounds in supercritical carbon dioxide, Fluid Phase Equilib. 254 (2007) 167-173

[3]

C. S. Su, Y. P. Chen, Measurement and correlation for the solid solubility of non-steroidal anti-inflammatory drugs (NSAIDs) in supercritical carbon dioxide, J. Supercrit. Fluids 43 (2008) 438-446

[4]

C. S. Su, Y. P. Chen, Recrystallization of pharmaceuticals using the batch supercritical anti-solvent process, Chem. Eng. Process. 48 (2009) 92-100

[5]

C. S. Su, Y. P. Chen, Micronization of nabumetone using the rapid expansion of supercritical solutions (RESS) process, J. Supercrit. Fluids 50 (2009) 69-76

[6]

Y. J. Tien, C. S. Su, L. H. Lien, Y. P. Chen, Recrystallization of erlotinib hydrochloride and fulvestrant using supercritical anti-solvent process, J. Supercrit. Fluids 55 (2010) 292-299

[7]

C. S. Su, Y. M. Chen, Y. P. Chen, Correlation of solid solubilities for phenolic compounds and steroids in supercritical carbon dioxide using the solution model, J. Taiwan Inst. Chem. Eng. 42 (2011) 608-615

[8]

P. C. Lin, C. S. Su, M. Tang, Y. P. Chen, Micronization of tolbutamide using rapid expansion of supercritical solution with solid co-solvent (RESS-SC) process, Res. Chem. Intermed. 37 (2011) 153-163

[9]

C. S. Su, W. S. Lo, L. H. Lien, Micronization of fluticasone propionate using supercritical antisolvent process, Chem. Eng. Technol. 34 (2011) 535-541

2. 國內期刊論文

[1]

蘇至善, 榮榮贊, 陳延平, 利用超臨界流體技術生產固體微粒之研發, 化工技術, 11:10 (2003) 160-169

[2]

蘇至善, 陳延平, 應用超臨界流體技術進行藥物微粒化之研發, 化工技術, 15:7 (2007) 168-178

[3]

蘇至善, 羅偉碩, 連凌霄, 利用超臨界反溶劑沉積法進行原料藥物性控制之研發, 化工技術, 19:1 (2011) 68-77

3. 國際研討會論文

[1]

C. S. Su, M. Tang, Y. P. Chen, Volume expansion calculation of solvents and carbon dioxide at elevated pressure, 2nd International Symposium on Supercritical Fluid Technology for Energy and Environment Applications (Super Green 2003), Nagoya, Japan, November, 2003

[2]

C. S. Su, M. Tang, Y. P. Chen, P. J. Lien, Recrystallization of mefenamic acid using the batch supercritical anti-solvent precipitation, 3rd International Symposium on Supercritical Fluid Technology for Energy and Environment Applications (Super Green 2004), Tianjin, China, October, 2004

[3]

C. S. Su, Y. P. Chen, Calculation of volume expansion in high pressure anti-solvent processes using the volume-translated Peng-Robinson equation of state, 4th International Symposium on Supercritical Fluid Technology for Energy and Environment Applications (Super Green 2005), Taipei, Taiwan, November, 2005

[4]

Y. P. Chang, C. S. Su, Y. P. Chen, Recrystallization and micronization of pharmaceuticals using the continuous supercritical anti-solvent (SAS) process, 4th International Symposium on Supercritical Fluid Technology for Energy and Environment Applications (Super Green 2005), Taipei, Taiwan, November, 2005

[5]

Y. P. Chang, C. S. Su, M. Tang, Y. P. Chen, Recrystallization of acetaminophen and sulindac from the batch and continuous supercritical anti-solvent precipitation, International Conference on High Pressure Science and Technology (Joint 20th AIRAPT - 43rd EHPRG), Karlsruhe, Germany, June, 2005 

[6]

J. J. Chen, C. S. Su, M. Tang, Y. P. Chen, Recrystallization and micronization of polymeric and pharmaceutical materials using the supercritical anti-solvent method, Joint Meeting of 8th International Symposium on Hydrothermal Reactions & 7th International Conference on Solvothermal Reactions (ISHR & ICSTR 2006), Sendai, Japan, August, 2006

[7]

C. S, Su, M. Tang, Y. P. Chen, Calculation of thermodynamic properties for the supercritical anti-solvent process using the predictive Soave-Redlich -Kwong (PSRK) equation of state, 8th International Symposium on Supercritical Fluids (ISSF 2006), Kyoto, Japan, November, 2006

[8]

C. S. Su, Y. M. Chen, Y. P. Chen, M. Tang, Correlation of solid solubility for phenolic compounds in supercritical carbon dioxide using a solution model approach, International Conference on Supercritical Fluids (Super Green 2007), Seoul, Korea, November, 2007

[9]

C. S. Su, Y. P. Chen, M. Tang, S. L. Ho, Recrystallization and micronization of phenylbutazone and nabumetone using the rapid expansion of supercritical solution (RESS) process, 9th International Symposium on Supercritical Fluids (ISSF 2009), Arcachon, France, May, 2009.

[10]

C. S. Su,  Y. H. Chiu, Y. P. Chen, Prediction of the volumetric properties of CO2 expanded solvent using predictive Soave-Redlich-Kwong (PSRK) equation of state, 7th International Symposium on Supercritical Fluids (Super Green 2011), Beijing, China August, 2011

4. 國內研討會論文

[1]

R. Y. Peng, Y. C. Tsai, C. Y. La, M. C. Huang, C. Cheng, C. S. Su, B. H. Lee, Solid itaconic acid fermentation by an adjuster-attached bioreactor, 第二屆生化工程研討會, 台北, June, 1997

[2]

R. Y. Peng, C. S. Su, K. C. Hsu, I. H. Yang, Activity of immobilized Aspergillus niger NTIT 80 on reactive polyurethane packed in a trickle-bed bioreactor, 中華民國微生物學年會, 台北, December, 1997

[3]

R. Y. Peng, C. Cheng, K. C. Hsu, C. S. Su, Y. H. Yang, Evaluation of nitrogen and phosphate removal efficiency of the trickle-bed bioreactor (TBBR) in aqua pond water, 第三屆生化工程研討會, 花蓮, June, 1998

[4]

R. Y. Peng, C. Cheng, C. S. Su, K. H. Hsu, C. Y. Huang, Chloride-tolerant A2O (anaerobic-anoxic-oxic) bioreactor, 第三屆生化工程研討會, 花蓮, June, 1998

[5]

R. Y. Peng, C. S. Su, K. H. Hsu, C. Y. Huang, Nitrogen and phosphate removal by chloride-tolerant A2O (anaerobic-anoxic-oxic) bioreactor, 中華民國微生物學年會, 台北, December, 1998

[6]

R. Y. Peng, C. S. Su, C. Cheng, G. M. Wu, Y. W. Lien, Immobilized chloride-tolerant A2O (anaerobic-anoxic-oxic) reactor for N- and P- removals - immobilization and activity stabilization technology, 第四屆生化工程研討會, 嘉義, June, 1999

[7]

蘇至善, 陳延平, 連培榮, 以批式超臨界反溶劑沉積法進行對-乙醯胺基酚與對-乙醯胺基苯乙醚之再結晶研究, 第三屆2004年超臨界流體技術應用與發展研討會, 台北, November, 2004

[8]

陳延平, 蘇至善, 陳彥銘, 陳宗勤, 連培榮, 以超臨界流體技術進行藥物微粒與生醫材料之製備, 第五屆2006年超臨界流體技術應用與發展研討會, 高雄, November, 2006

[9]

陳彥銘, 蘇至善, 陳延平, 應用溶液模式關聯酚類物質在超臨界二氧化碳中之溶解度, 第六屆2007年超臨界流體技術應用與發展研討會, 台中, December, 2007

[10]

蘇至善, 陳延平, 曾梨子, 利用快速膨脹法進行PhenylbutazoneNabumetone之再結晶與微粒化研究, 第七屆2008年超臨界流體技術應用與發展研討會, 台北, October, 2008

[11]

田耀鈞, 蘇至善, 連凌霄, 陳延平, 利用超臨界反溶劑沉積法進行抗癌藥物erlotinib hydrochloride 之再結晶研究, 第八屆2009年超臨界流體技術應用與發展研討會, 高雄, December, 2009

[12]

C. S. Su, W. S. Lo, W. W. Lin and L. H. Lien, Crystallization study of capecitabine using process analytical technology (PAT) and design of experiments (DOEs) approach, 台灣化學工程學會56週年年會, 台中, November, 2009

[13]

C. S. Su, W. S. Lo and L. H. Lien, Micronization of fluticasone propionate using the spiral jet mill, sonocrystallization and supercritical anti-solvent process, 台灣化學工程學會56週年年會, 台中, November, 2009

[14]

蘇至善, 羅偉碩, 連凌霄, 利用超臨界反溶劑沉積法進行藥物微粒化之研究, 超臨界流體技術應用與產業化說明會, 台北, January, 2010

[15]

蘇至善, 陳延平, Predictive Soave-Redlich-Kwong (PSRK)狀態方程式進行二氧化碳膨脹有機溶劑之體積性質預測, 第十屆2011年超臨界流體技術應用與發展研討會, 嘉義, October, 2011

[16]

蘇至善, 利用預測型Soave-Redlich-Kwong (PSRK) 狀態方程式進行固體溶質於二氧化碳膨脹有機溶劑中之溶解度預測, 台灣化學工程學會58週年年會, 台南, November, 2011